Accepted for Publication: August 1, 2013.
Published Online: October 7, 2013. doi:10.1001/jamainternmed.2013.11362.
Study concept and design: Than, Aldous, Goodacre, Frampton, George, Ardagh, Jardine, Cullen, Richards, Hamilton, Deely.
Acquisition of data: Than, Aldous, Troughton, George, Florkowski, Smyth, Richards.
Analysis and interpretation of data: Than, Lord, Goodacre, Troughton, George, Ardagh, Peacock, Young, Deely, Cullen, Richards.
Drafting of the manuscript: Than, Lord, Young, Deely, Cullen.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Lord, Frampton.
Obtained funding: Than, Goodacre, Troughton, Hamilton, Richards.
Administrative, technical, and material support: Than, Aldous, Troughton, George, Florkowski, Ardagh, Smyth, Jardine, Deely, Richards.
Study supervision: Troughton, George, Ardagh, Jardine, Cullen.
Conflict of Interest Disclosures: Dr Than has received funding from Alere, Abbott, Beckman, and Roche for speaking and support for other research. Dr Goodacre has received funding from the UK National Institute for Health Research for chest pain trials. Dr George receives funding from Abbott, Beckman Coulter, and Roche for speaking. Dr Ardagh has received funding from the Health Research Council, New Zealand (HRCNZ) for unrelated research. Dr Peacock has received research grants from Abbott, Alere, Brahms, Novartis, Roche, and The Medicines Company; has been a consultant for Abbott, Alere, Lily, The Medicines Company; has been a speaker for Bureau Abbott, Alere, and EKjmR; and had ownership interest in Comprehensive Research Associates LLC, Vital Sensors, and Emergencies in Medicine LLC. Dr Deely receives funding from the Emergency Care Foundation for medical writing and HRCNZ for unrelated research. Dr Cullen has received funding from Abbott Diagnostics, Roche, Alere, Siemens, and Radiometer Pacific for clinical trials, and from Alere, Boehringer Ingelheim, Pfizer, AstraZenica, Abbott Diagnostics, and Radiometer Pacific for speaking and education. Dr Richards receives speaker honoraria from Roche Dx and Alere. No other disclosures were reported.
Funding/Support: Financial support for this study was provided by the Health Research Council of New Zealand and Canterbury District Health Board.
Role of the Sponsor: The HRCNZ and Canterbury District Health Board had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: The following Canterbury District Health Board staff contributed to the study. Coordination support: Lorraine Skelton, RN, Viki Robinson, BA, RComp N, and Deidre Krause, RN. Data management: Barabara Neame, BTech and Nick Davis, Equipment coordination: Kay Ratahi. Recruitment, phlebotomy, and telephone follow-up: Becky Hayston, BNurs, Carol Groves, RGON, Cindy Dorset, Jackie Hughs, RN, Joanne Davies, RN, MSc, Judy Heslop, NZCS, Debra Latimer, BA, PGCCPC, BN, RN, DipParamedSci, Deidre Krause, RN, Nikki Ross, RN, Sara Raudsepp, PGDipHealSci, Felicity Turner, NZRN, Jane Byrne, BSC Hons, Marlene Batchelor, BA, Mike O’Callaghan, RN, Ruth Jardine, RGON, BN, and Susan O’Brien, BA. ECG and diagnosis adjudication: Mark Baily, MBChB, PGDipMSM. Protocol development: Helen Kleindienst, BSc. Senior management support: Anne Esson, RGON, ADipN, BA, Carolyn Gullery, BSc, and David Meates, BAgSci. As staff, all received salary support but no additional payment from the authors.