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Comment and Response |

Is 81-mg Aspirin Associated With Age-Related Macular Degeneration Risk?—Reply

Jie Jin Wang, MMed, PhD1,2; Gerald Liew, MBBS, PhD1,2; Paul Mitchell, MD, PhD1
[+] Author Affiliations
1Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
2Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
JAMA Intern Med. 2013;173(15):1476-1477. doi:10.1001/jamainternmed.2013.8131.
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In Reply We completely agree with Dr Keller about the importance of having aspirin intake dose information and his comment about what we reported was “time dose” or use duration-dose pattern but not quantitative dose of aspirin intake. If an intake dose-response pattern were found with the aspirin dose data, this would strengthen the evidence supporting an association between aspirin use and age-related macular degeneration (AMD) and inform clinical practice. However, we do not have precise dosage data collected from our study sample.

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August 12, 2013
David L. Keller, MD
1Providence Medical Group, Torrance, California
JAMA Intern Med. 2013;173(15):1476. doi:10.1001/jamainternmed.2013.8147.
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