Accepted for Publication: January 31, 2013.
Published Online: May 20, 2013. doi: 10.1001/jamainternmed.2013.1016
Study concept and design: Gershon, Croxford, Stanbrook, Upshur, and Stukel.
Acquisition of data: Gershon and Calzavara.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Gershon, Croxford, and Upshur.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Croxford, Calzavara, Stanbrook, and Stukel.
Obtained funding: Gershon.
Administrative, technical, and material support: Gershon and Upshur.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by the government of Ontario; by the Institute for Clinical Evaluative Sciences (ICES), which is funded by an annual grant from the Ontario Ministry of Health and Long-term Care; by a Career Scientist Award from the Ontario Ministry of Health and Long-term Care (Dr Gershon); by a New Investigator Award funded by team grant OTG-88591 from the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and Diabetes (Dr Gershon); and by The Dales Award in Medical Research from the University of Toronto (Dr To). Brogan Inc, Ottawa, permitted use of their Drug Product and Therapeutic Class Database.
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Disclaimer: The opinions, results, and conclusions reported in this study are those of the authors and are independent from the funding sources. No endorsement by the ICES or the Ontario Ministry of Health and Long-term Care is intended or should be inferred.
Previous Presentation: This study was presented at the 2011 American Thoracic Society International Conference; May 16, 2011; Denver, Colorado.