Published Online: July 1, 2013. doi:10.1001/jamainternmed.2013.7783.
Study concept and design: Solomon, Kirwan.
Acquisition of data: Solomon, Karstoft, Haus, Kirwan.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Solomon, Malin, Kirwan.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Solomon, Malin.
Obtained funding: Solomon, Malin, Kirwan.
Administrative, technical, and material support: All authors.
Study supervision: Solomon, Kirwan.
Conflict of Interest Disclosures: None reported.
Funding/Support: The study was funded by a Paul Langerhans program grant from the European Foundation for the Study of Diabetes (Dr Solomon) and was supported by grant RO1 AG12834 from the National Institute of Health (Dr Kirwan) and Clinical and Translational Science Award UL1 RR024989. Dr Malin was supported by NIH grant T32 DK007319.
Role of the Sponsors: The funding sources played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.
Trial Registration: clinicaltrials.gov Identifier: NCT01234155
Additional Contributions: Lisbeth Andreasen, MSc (Rigshospitalet, Denmark), assisted with biochemical analyses and Julianne Filion, RN (Cleveland Clinic, Cleveland, Ohio), assisted with subject recruitment and patient screening. Marc Cook, MSc (Cleveland Clinic), Thomas Grøndahl, MSc (Rigshospitalet), and Kamilla Winding, MSc (Rigshospitalet), helped with exercise training.