Accepted for Publication: February 28, 2013.
Published Online: June 10, 2013. doi:10.1001/jamainternmed.2013.6883.
Study concept and design: Landman, van Hateren, Logtenberg, Bilo, and Kleefstra.
Acquisition of data: Landman, Drion, van Hateren, van Dijk, and Lambert.
Analysis and interpretation of data: Landman, Lambert, Groenier, and Bilo.
Drafting of the manuscript: Landman and Drion.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: van Hateren and Groenier.
Obtained funding: Bilo.
Administrative, technical, and material support: Landman, Drion, van Dijk, and Lambert.
Study supervision: Bilo and Kleefstra.
Conflict of Interest Disclosures: None reported.
Funding/Support:InterCure Ltd provided the RESPeRATE and sham devices.
Role of the Sponsors: The trial was sponsored by the Medical Research Foundation Zwolle.
Additional Contributions: We thank all the patients who participated in this trial. Ineke Kloppenberg, as well as Sabine Diepeveen, MD, PhD, Ad Kamper, MD, PhD, and Jan-Evert Heeg, MD, PhD, assisted with the inclusion.