Accepted for Publication: February 18, 2013.
Author Contributions: Dr Yaffe had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept or design: Yaffe.
Acquisition of data: Harris, Simonsick, Schwartz.
Analysis and interpretation of data: Yaffe, Hamilton, Simonsick, Schwartz.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hamilton.
Obtaining funding: Yaffe.
Study supervision: Yaffe, Schwartz.
Published Online: June 10, 2013. doi:10.1001/jamainternmed.2013.6176.
Conflict of Interest Disclosures: Dr Yaffe has served on data safety monitoring boards for Takeda Inc, Pfizer Inc, and Medivation Inc and served as a consultant for Novartis Inc.
Funding/Support: This study was supported by grants N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106 from the National Institute on Aging and by grants R01-AG028050 and R01-NR012459 from the National Institute of Nursing Research. This research was supported in part by the Intramural Research Program of the National Institutes of Health, by the National Institute on Aging, and by grant A201-0029 from the American Health Assistance Foundation. Dr Yaffe is supported in part by grant K24AG031155 from the National Institute on Aging.
Health ABC Study Principal Investigators and Staff:Clinical sites: University of Pittsburgh, Pittsburgh, Pennsylvania: Anne B. Newman, MD, MPH, principal investigator, and Diane Ives, study coordinator; University of Tennessee, Memphis: Suzanne Satterfield, MD, DrPH, principal investigator, and Jan Elam, study coordinator; Health ABC Coordinating Center: Steven R. Cummings, MD, and Michael C. Nevitt, PhD, principal investigators, Susan M. Rubin, MPH, project director; Sponsor: Tamara B. Harris, MD, and Melissa E. Garcia, MPH, National Institute on Aging (project office).