Accepted for Publication: December 21, 2012.
Published Online: April 8, 2013. doi:10.1001/jamainternmed.2013.319
Author Contributions: Dr Deaño and Ms Glassner-Kolmin served as co–first authors, each with equal contribution to the manuscript. Dr Deaño and Ms Glassner-Kolmin had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Dr Gomberg-Maitland assumes full responsibility for the submission as a whole. Study concept and design: Deaño, Rubenfire, Frost, and Gomberg-Maitland. Acquisition of data: All authors. Analysis and interpretation of data: Deaño, Glassner-Kolmin, Rubenfire, Frost, McLaughlin, and Gomberg-Maitland. Drafting of the manuscript: Deaño, Glassner-Kolmin, and Gomberg-Maitland. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: Deaño, Frost, and Gomberg-Maitland. Administrative, technical, and material support: Glassner-Kolmin, Frost, and Gomberg-Maitland. Study supervision: Rubenfire, Frost, and Gomberg-Maitland.
Conflict of Interest Disclosures: Dr Rubenfire has received grants from Actelion, Gilead, Bayer, Novartis, and United Therapeutics in support of clinical research. Dr Frost is a consultant for Bayer, Novartis, Aires, and Ikaria; is a speaker or member of the speaker's bureau for Gilead and United Therapeutics; and has received grants from Gilead, Actelion, Pfizer, United Therapeutics, Aires, Bayer, Novartis, Ikaria, GSK, and Sanofi-Aventis in support of clinical research. Dr McLaughlin has consulted for Actelion, Bayer, Gilead, and United Therapeutics; was a member of the speaker's bureau for Actelion (ending October 2011) and is a member of the speaker's bureau for Gilead and United Therapeutics; and has provided research support for Actelion, Bayer, and Novartis. The University of Chicago has received research grant support for Dr Gomberg-Maitland to be principal investigator for clinical trials from Actelion, Gilead, GSK, Medtronic, Novartis, and United Therapeutics; she has also served as a consultant and on steering, data safety monitoring, and events committees for these companies and Ikaria.
Previous Presentations: This research was presented in part at the 32nd Annual Meeting of the International Society for Heart and Lung Transplantation; April 19, 2012; Prague, Czech Republic; the International Conference of the American Thoracic Society; May 22, 2012; San Francisco, California; and the 10th International Conference of the Pulmonary Hypertension Association; June 22, 2012; Orlando, Florida.