Prior studies have shown that 25% to 50% of clinical trials are never published.1- 4 However, among those published, we know little about the length of time required for publication in the peer-reviewed biomedical literature after study completion. Ioannidis5 previously demonstrated that a sample of randomized phase 2 and 3 trials conducted between 1986 and 1996 required nearly 2.5 years for publication, while our more recent study of National Institutes of Health (NIH)-funded trials found that the average time to publication was almost 2 years.4 We sought to determine time to publication for a recent and representative sample of trials published in 2009.
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