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Research Letters |

Time to Publication Among Completed Clinical Trials

Joseph S. Ross, MD, MHS; Marian Mocanu, MD; Julianna F. Lampropulos, MD; Tony Tse, PhD; Harlan M. Krumholz, MD, SM
JAMA Intern Med. 2013;173(9):825-828. doi:10.1001/jamainternmed.2013.136.
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Prior studies have shown that 25% to 50% of clinical trials are never published.14 However, among those published, we know little about the length of time required for publication in the peer-reviewed biomedical literature after study completion. Ioannidis5 previously demonstrated that a sample of randomized phase 2 and 3 trials conducted between 1986 and 1996 required nearly 2.5 years for publication, while our more recent study of National Institutes of Health (NIH)-funded trials found that the average time to publication was almost 2 years.4 We sought to determine time to publication for a recent and representative sample of trials published in 2009.

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