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Research Letters |

Using Information Technology to Improve the Monitoring of Outpatient Prescribing

Alan J. Forster, MD, MSc; Claudine Auger, PhD; for the ISTOP ADE Investigators
JAMA Intern Med. 2013;173(5):382-384. doi:10.1001/jamainternmed.2013.2002.
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Adverse drug events (ADEs) and medication nonadherence are common and reduce the potential benefit of medications. Adverse drug events, defined as poor health outcomes caused by medications,1 occur in up to 25% of ambulatory care patients prescribed a medication.2Medication nonadherence, defined as patients not taking their medications as directed,3 can occur in 25% of new prescriptions.2,45 Improved monitoring and communication could reduce ADEs and nonadherence to minimize medication-associated problems.

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Figure. Graphic representation of data flow through the ISTOP monitoring system. (1) At the time of prescription, primary care physicians receive electronic prompt identifying eligible patients; this information is based on a query of the patient's prescription history within the clinical data repository. (2) When the patient's eligibility is confirmed and the patient consents, primary care physicians enroll consenting patients into the program. (3) The system's electronic health record (Medical Office of the 21st Century web-based electronic prescribing and integrated drug management [MOXXI] system6) passes data to the interactive voice response system (IVRS) to queue automated follow-up calls. (4) The IVRS calls patients and administers the questionnaire on days 3 and 17 after the prescription; the questionnaire consists of 4 simple questions soliciting “yes” or “no” answers (med indicates the subject prescription medication). (5) The IVRS passes patient response data to MOXXI to update the electronic health record. (6) The IVRS sends an e-mail to the study pharmacist if responses by the patient indicate that follow-up is required. (7) The pharmacist personally contacts patients and documents information in the MOXXI system.

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