A recent editorial highlights the debate regarding where to place cluster RCTs in the research hierarchy.3 Two paired articles in a high-impact journal reached different conclusions regarding routine screening and gown and glove precautions for patients with multidrug-resistant bacterial colonization. One article,4 a quasiexperimental before-and-after study, found that the practice worked, while another,5 a multicenter cluster RCT, found no benefit. If an observational study reaches a different result than an RCT, most would conclude the RCT got it right (ie, hormone therapy and cardiovascular risk, beta carotene therapy and cancer prevention). Yet, in the case of contact precautions, the editorial was ambivalent.3 Ambivalence would be reasonable if cluster RCTs are more likely to reach negative conclusions than RCTs. We sought to examine this hypothesis. Herein, we provide a comparison of cluster RCTs and traditional RCTs for the 50 highest-cited articles (to compare high-impact work) and the most recent 50 articles (to compare a random sampling).