Lazzarino et al evaluated 66 518 individuals representative of the general population in England for psychological distress. These individuals were categorized according to their socioeconomic status (SES) at baseline and followed up over 8 years for all-cause mortality. After adjustment for age, sex, smoking, body mass index, physical activity, hypertension, and diabetes, both psychological distress and low SES were associated with increased mortality rates. However, the association of psychological distress with mortality differed according to SES, with the strongest associations being observed in the lowest SES categories. The detrimental effect of psychological distress on mortality is amplified by low SES, and people in higher SES categories have lower mortality rates even when they report high levels of psychological distress.