Accepted for Publication: August 14, 2012.
Published Online: January 14, 2013. doi:10.1001/2013.jamainternmed.733
Author Contributions: Ms Gomes had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Gomes, Redelmeier, Juurlink, Dhalla, Camacho, and Mamdani. Acquisition of data: Gomes. Analysis and interpretation of data: Gomes, Redelmeier, Juurlink, Dhalla, Camacho, and Mamdani. Drafting of the manuscript: Gomes. Critical revision of the manuscript for important intellectual content: Redelmeier, Juurlink, Dhalla, Camacho, and Mamdani. Statistical analysis: Gomes and Redelmeier. Obtained funding: Gomes, Juurlink, and Mamdani. Administrative, technical, and material support: Mamdani. Study supervision: Redelmeier.
Conflict of Interest Disclosures: Dr Mamdani reported receiving honoraria from Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, and Pfizer.
Funding/Support: This study was supported by a grant from the Ontario Ministry of Health and Long-term Care Drug Innovation Fund and the Institute for Clinical Evaluative Sciences, a nonprofit research institute sponsored by the Ontario Ministry of Health and Long-term Care.
Disclaimer: The opinions, results, and conclusions reported in this article are those of the authors, and no endorsement by the sponsors is intended or should be inferred.
Additional Contributions: Brogan Inc permitted us to use their Drug Product and Therapeutic Class Database.