Accepted for Publication: August 13, 2012.
Published Online: December 31, 2012. doi:10.1001/2013.jamainternmed.997
Author Contributions: Dr Kesselheim had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Kesselheim, Misono, Shrank, Greene, Avorn, and Choudhry. Acquisition of data: Kesselheim, Misono, Shrank, and Doherty. Analysis and interpretation of data: Kesselheim, Misono, Shrank, Greene, Doherty, and Choudhry. Drafting of the manuscript: Kesselheim, Misono, and Greene. Critical revision of the manuscript for important intellectual content: Kesselheim, Misono, Shrank, Greene, Doherty, Avorn, and Choudhry. Statistical analysis: Shrank and Doherty. Administrative, technical, and material support: Misono, Shrank, and Doherty. Study supervision: Shrank, Avorn, and Choudhry.
Conflict of Interest Disclosures: Dr Choudhry has received unrestricted research grants from CVS Caremark, Aetna, the Commonwealth Fund, and the Robert Wood Johnson Foundation to study medication adherence. Dr Shrank has received unrestricted research funding from CVS Caremark, Aetna, Teva, Lilly, and the National Association of Chain Drug Stores.
Funding/Support: Dr Kesselheim's work is supported by a career development award from the Agency for Healthcare Research & Quality (K08HS18465-01), and a Robert Wood Johnson Foundation Investigator Award in Health Policy Research.
Role of the Sponsors: The funders had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: Joshua Gagne, PharmD, ScD, provided comments on the study design; Bo Wang, PharmD, and Helen Mogun, MS, helped with the research process (all with the Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School); and Ellen Bubrick, MD, (Department of Neurology, Brigham and Women's Hospital) provided comments on an earlier draft. Written permission has been obtained from all people mentioned.