Accepted for Publication: August 8, 2012.
Published Online: November 26, 2012. doi:10.1001/2013.jamainternmed.744
Author Contributions: Drs Alonso and Sotoodehnia had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Chen, Bůžková, Lopez, Heckbert, Soliman, Adabag, and Alonso. Acquisition of data: Sotoodehnia, Heckbert, Prineas, Soliman, Folsom, Siscovick, and Alonso. Analysis and interpretation of data: Chen, Sotoodehnia, Bůžková, Lopez, Yee, Heckbert, Adabag, Konety, Siscovick, and Alonso. Drafting of the manuscript: Chen, Bůžková, and Lopez. Critical revision of the manuscript for important intellectual content: Chen, Sotoodehnia, Bůžková, Lopez, Yee, Heckbert, Prineas, Soliman, Adabag, Konety, Folsom, Siscovick, and Alonso. Statistical analysis: Bůžková, Lopez, and Yee. Obtained funding: Heckbert, Prineas, Siscovick, and Alonso. Administrative, technical, or material support: Alonso. Supervision: Chen, Sotoodehnia, Heckbert, and Alonso.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by grant funding from the National Institutes of Health. The ARIC Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C. This CHS research was supported by contracts HHSN268201200036C, N01-HC-85239, N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, and N01-HC-45133, and grants HL080295 and HL102214 from the National Heart, Lung, and Blood Institute, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through AG-023629, AG-15928, AG-20098, and AG-027058 from the National Institute on Aging. This research was conducted while Dr Chen was a recipient of Scientist Development Grant 10SDG3420031 from the American Heart Association. This study was also supported in part by grants RC1 HL099452 (Dr Alonso), R01HL088456 (Dr Sotoodehnia), and R01 HL102214 (Dr Heckbert) from the National Heart, Lung, and Blood Institute and by grant 09SDG2280087 (Dr Alonzo) from the American Heart Association.
Role of the Sponsors: The funding agencies had no role in the design or conduct of the study; in the collection, management, analysis, or interpretation of the data; or in the preparation, review, or approval of the manuscript.
Previous Presentations: This study was presented at the American Heart Association Scientific Sessions; November 14, 2011; Orlando, Florida; and the Great Wall International Congress of Cardiology; October 13, 2012; Beijing, China.
Additional Information: A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm.