Accepted for Publication: July 16, 2012.
Published Online: November 19, 2012. doi:10.1001/2013.jamainternmed.469
Author Contributions: Dr Butt had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Butt, Mamdani, Tu, Gomes, and Glazier. Acquisition of data: Butt and Glazier. Analysis and interpretation of data: Butt, Mamdani, Austin, and Gomes. Drafting of the manuscript: Butt. Critical revision of the manuscript for important intellectual content: Butt, Mamdani, Austin, Tu, Gomes, and Glazier. Statistical analysis: Butt and Mamdani. Obtained funding: Butt. Administrative, technical, and material support: Butt, Mamdani, Tu, Gomes, and Glazier. Study supervision: Glazier.
Conflict of Interest Disclosures: Dr Mamdani reports that he is a consultant for Hoffman-La Roche, GlaxoSmithKline, Pfizer, Novartis, and Lilly and has received honoraria as a member of the advisory boards of AstraZeneca, Bristol-Myers Squibb, Lilly, GlaxoSmithKline, Hoffman-La Roche, Novartis, Novo Nordisk, and Pfizer.
Funding/Support: This work was funded by the Ontario Ministry of Health and Long-Term Care, a Career Investigator Award from the Heart and Stroke Foundation of Ontario (Dr Austin), and a Canadian Institutes of Health Research Fellowship Award in Primary Care (Dr Tu).
Role of the Sponsor: The sponsor did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Disclaimer: The opinions, results, and conclusions are those of the authors and no endorsement by the Ministry of Health and Long-Term Care or by the Institute for Clinical Evaluative Sciences is intended or should be inferred.
Additional Contributions: We thank Paddy Farrington, PhD (Division of Statistics, Open University, Milton Keynes, England), for his contribution to the study design and analytical assistance, and Alex Kopp, BSc, and Zhongliang Chen, MD, MSc (both of the Institute for Clinical Evaluative Sciences), for their help with the data preparation.