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Research Letters |

Management of Substance Use Disorders in Ambulatory Care in the United States, 2001-2009 FREE

Joseph W. Frank, MD; John Z. Ayanian, MD, MPP; Jeffrey A. Linder, MD, MPH
[+] Author Affiliations

Author Affiliations: Division of General Medicine and Primary Care, Brigham and Women's Hospital (Drs Frank, Ayanian, and Linder); Department of Health Care Policy (Dr Ayanian), Harvard Medical School (Drs Frank and Linder); and Department of Health Policy and Management, Harvard School of Public Health (Dr Ayanian); Boston, Massachusetts.


Arch Intern Med. 2012;172(22):1759-1760. doi:10.1001/archinternmed.2012.4504.
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Published online

An estimated 22.5 million Americans meet criteria for a substance use disorder diagnosis.1 Opioid use, in particular, has attracted attention recently because overdose deaths due to opioid analgesics have increased nearly 4-fold in the past decade.2 Effective treatment options have also increased during this period.3 The impact of these developments on the delivery of substance abuse treatment in traditional ambulatory care settings is not known. Further change is expected as recent federal legislation is implemented.4 Therefore, we sought to describe the prevalence and management of substance use disorders in ambulatory care in a nationally representative sample.

We analyzed data from the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS) from 2001 through 2009. The NAMCS and the NHAMCS are nationally representative cross-sectional surveys of ambulatory visits administered by the National Center for Health Statistics (NCHS).5,6 Survey data include up to 3 diagnoses coded using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and up to 3 reasons for the visit coded using the NCHS Reason for Visit Classification. We identified visits by individuals 18 years or older in which a diagnosis or complaint of an alcohol or drug use disorder (defined as dependence, abuse, withdrawal, or intoxication) was recorded. We defined pharmacotherapy as the provision of any 1 of 5 medications approved by the US Food and Drug Administration for alcohol or opioid use disorders: buprenorphine, methadone, acamprosate, disulfiram, and naltrexone.3 We defined psychosocial therapy as the provision of psychotherapy, mental health counseling, or stress management. We evaluated differences in proportions with the χ2 test and trends with the Cochran-Mantel-Haenszel test. We used multivariable logistic regression to identify predictors of management, adjusting for patient- and practice-level characteristics as well as time period. We performed analyses using SAS version 9.3 (SAS Institute Inc) and SAS-callable SUDAAN release 10.0.1 (Research Triangle Institute) to account for the complex survey design.

We analyzed 8930 visits, representing an estimated 42.2 million adult visits involving substance use disorders in ambulatory settings between 2001 and 2009. Visits increased 70% over this period, from 10.6 million in 2001 through 2003 to 18.0 million in 2007 through 2009 (P = .006; Figure). Visits for opioid use disorders increased 6-fold from 772 000 in 2001 through 2003 to 4.4 million in 2007 through 2009, accounting for 7% of all substance use disorder visits in 2001 through 2003 and 25% of visits in 2007 through 2009 (P = .004).

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Trends in estimated adult visits for substance use disorders by diagnosis (A) and management (B) from 2001 through 2009. (Data are from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey.)

Physicians prescribed pharmacotherapy in 6.3 million visits, representing 15% of all substance use disorder visits. These visits increased more than 6-fold, from an estimated 643 000 visits in 2001 through 2003 to 3.9 million visits in 2007 through 2009 (P < .001). Physicians prescribed buprenorphine or methadone in 4.8 million visits and acamprosate, disulfiram, or naltrexone in 1.5 million visits. Physicians provided psychosocial therapy in an estimated 24.9 million visits, representing 59% of all visits. This proportion did not change significantly over time (P = .87). In multivariable models, time period was independently associated with pharmacotherapy (odds ratio [OR], 3.3 for 2007-2009 vs 2001-2003; 95% CI, 1.7-6.1) but not psychosocial therapy (OR, 0.8 for 2007-2009 vs 2001-2003; 95% CI, 0.5-1.3). However, neither therapy was provided in 15.4 million visits, accounting for 36% of visits and not varying significantly over time (P = .76).

In this nationally representative sample of adult ambulatory visits, visits involving a substance use disorder increased substantially between 2001 and 2009. Opioid use disorders accounted for a markedly increased share of visits over time. This finding is consistent with trends in substance use disorder–related utilization at the nation's community health centers and emergency departments and, sadly, use of its morgues.2,7,8 Our study provides reason for optimism, however. Visits involving provision of pharmacotherapy increased as well, likely driven by the use of buprenorphine. Increasing recognition of previously undiagnosed disorders, improving familiarity with and use of available medications, and more frequent ambulatory care by individuals with substance use disorders all likely contribute to the trend of increasing visits over time. As millions of visits did not involve treatment, there remains both an opportunity and a need for further expansion of treatment within ambulatory settings.

Our study has several limitations. First, the cross-sectional, visit-based nature of the data precludes causal inferences. Residual confounding is possible, and underdiagnosis is likely. Finally, the NAMCS/NHAMCS lacks detailed clinical information, so we could not assess the appropriateness of management decisions by health care providers.

The Mental Health Parity and Addiction Equity Act of 2008 (Pub L No. 110-343) and the Patient Protection and Affordable Care Act of 2010 (Pub L No. 111-148) will provide increased support for the management of substance use disorders in ambulatory settings.4 Our study provides an important assessment of the national impact of substance use disorders in ambulatory care at a time when these laws have the potential to transform the US health care system's ability to care for the millions of Americans struggling with these disorders.

Correspondence: Dr Frank, Division of General Medicine and Primary Care, Brigham and Women's Hospital, 1620 Tremont St, Third Floor, Boston, MA 02120 (jfrank@partners.org).

Published Online: October 22, 2012. doi:10.1001/archinternmed.2012.4504

Author Contributions: Dr Frank had full access to all of the study data, which are publicly available from the National Center for Health Statistics, and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Frank, Ayanian, and Linder. Acquisition of data: Frank. Analysis and interpretation of data: Frank, Ayanian, and Linder. Drafting of the manuscript: Frank and Linder. Critical revision of the manuscript for important intellectual content: Ayanian and Linder. Statistical analysis: Frank and Linder. Obtained funding: Ayanian. Administrative, technical, and material support: Linder. Study supervision: Frank, Ayanian, and Linder.

Conflict of Interest Disclosures: None reported.

Funding/Support: Dr Frank is supported by the Health Resources and Services Administration through an institutional National Research Service Award (T32HP10251).

Role of the Sponsor: The Health Resources and Services Administration had no role in the design or conduct of the study; the collection, management, analysis or interpretation of the data; or the preparation, review or approval of the manuscript.

Previous Presentation: An abstract of this study was presented at the Society of General Internal Medicine Annual Meeting; May 9, 2012; Orlando, Florida.

Substance Abuse and Mental Health Services Administration.  Results From the 2009 National Survey on Drug Use and Health: Volume I: Summary of National Findings. Rockville, MD: US Dept of Health and Human Services; 2010
Centers for Disease Control and Prevention (CDC).  Vital signs: overdoses of prescription opioid pain relievers—United States, 1999-2008.  MMWR Morb Mortal Wkly Rep. 2011;60(43):1487-1492
PubMed
Mark TL, Kassed CA, Vandivort-Warren R, Levit KR, Kranzler HR. Alcohol and opioid dependence medications: prescription trends, overall and by physician specialty.  Drug Alcohol Depend. 2009;99(1-3):345-349
PubMed   |  Link to Article
Buck JA. The looming expansion and transformation of public substance abuse treatment under the Affordable Care Act.  Health Aff (Millwood). 2011;30(8):1402-1410
PubMed   |  Link to Article
Hsiao CJ, Cherry DK, Beatty PC, Rechtsteiner EA. National Ambulatory Medical Care Survey: 2007 summary.  Natl Health Stat Report. 2010;(27):1-32
PubMed
Hing E, Hall MJ, Ashman JJ, Xu J. National Hospital Ambulatory Medical Care Survey: 2007 outpatient department summary.  Natl Health Stat Report. 2010;(28):1-32
PubMed
Druss BG, Bornemann T, Fry-Johnson YW, McCombs HG, Politzer RM, Rust G. Trends in mental health and substance abuse services at the nation's community health centers: 1998-2003.  Am J Public Health. 2008;98(9):(suppl)  S126-S131
PubMed   |  Link to Article
Centers for Disease Control and Prevention (CDC).  Emergency department visits involving nonmedical use of selected prescription drugs—United States, 2004-2008.  MMWR Morb Mortal Wkly Rep. 2010;59(23):705-709
PubMed

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Trends in estimated adult visits for substance use disorders by diagnosis (A) and management (B) from 2001 through 2009. (Data are from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey.)

Tables

References

Substance Abuse and Mental Health Services Administration.  Results From the 2009 National Survey on Drug Use and Health: Volume I: Summary of National Findings. Rockville, MD: US Dept of Health and Human Services; 2010
Centers for Disease Control and Prevention (CDC).  Vital signs: overdoses of prescription opioid pain relievers—United States, 1999-2008.  MMWR Morb Mortal Wkly Rep. 2011;60(43):1487-1492
PubMed
Mark TL, Kassed CA, Vandivort-Warren R, Levit KR, Kranzler HR. Alcohol and opioid dependence medications: prescription trends, overall and by physician specialty.  Drug Alcohol Depend. 2009;99(1-3):345-349
PubMed   |  Link to Article
Buck JA. The looming expansion and transformation of public substance abuse treatment under the Affordable Care Act.  Health Aff (Millwood). 2011;30(8):1402-1410
PubMed   |  Link to Article
Hsiao CJ, Cherry DK, Beatty PC, Rechtsteiner EA. National Ambulatory Medical Care Survey: 2007 summary.  Natl Health Stat Report. 2010;(27):1-32
PubMed
Hing E, Hall MJ, Ashman JJ, Xu J. National Hospital Ambulatory Medical Care Survey: 2007 outpatient department summary.  Natl Health Stat Report. 2010;(28):1-32
PubMed
Druss BG, Bornemann T, Fry-Johnson YW, McCombs HG, Politzer RM, Rust G. Trends in mental health and substance abuse services at the nation's community health centers: 1998-2003.  Am J Public Health. 2008;98(9):(suppl)  S126-S131
PubMed   |  Link to Article
Centers for Disease Control and Prevention (CDC).  Emergency department visits involving nonmedical use of selected prescription drugs—United States, 2004-2008.  MMWR Morb Mortal Wkly Rep. 2010;59(23):705-709
PubMed

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