Editor's Correspondence |

Antipsychotic Drugs and Myocardial Infarction in Patients With Dementia

Chittaranjan Andrade, MD; Praveen Paul Fernandes, MD
Arch Intern Med. 2012;172(18):1428-1429. doi:10.1001/archinternmed.2012.3761.
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Pariente et al1 conducted a retrospective study of prescription claims data and found that, in elderly patients receiving anticholinesterase medications, antipsychotic dispensing was associated with an increased risk of myocardial infarction only during the first 2 months following antipsychotic initiation; in matched cohort and self-controlled analyses, there was no statistically significant elevation in infarction risk during subsequent periods, extending to a year after antipsychotic initiation and beyond.

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Antipsychotic drugs and myocardial infarction in patients with dementia. Arch Intern Med 2012;172(18):1428-9; author reply 1429-30.
Study findings hard to interpret. Arch Intern Med 2012;172(18):1429; author reply 1429-30.

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