Accepted for Publication: June 4, 2012.
Published Online: September 17, 2012. doi:10.1001/archinternmed.2012.4261
Author Contributions: The principal investigator, Dr Witt, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Witt, Delate, Garcia, Clark, and Dentali. Acquisition of data: Witt, Delate, Garcia, and Clark. Analysis and interpretation of data: Witt, Delate, Garcia, Hylek, Ageno, and Dentali. Drafting of the manuscript: Witt, Delate, Garcia, and Dentali. Critical revision of the manuscript for important intellectual content: Witt, Garcia, Clark, Hylek, Ageno, and Dentali. Statistical analysis: Witt and Delate. Obtained funding: Witt and Garcia. Administrative, technical, and material support: Garcia and Clark. Study supervision: Witt and Ageno.
Financial Disclosure: Dr Garcia has served as an advisor to Boehringrer Ingelheim, Bristol-Meyers Squibb, Daiichi Sankyo, and CSL Behring. Dr Hylek has served as an advisor to Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Johnson and Johnson, and Pfizer and participated in clinical symposia sponsored by Bayer, Boehringer Ingelheim, and Bristol-Myers Squibb. Dr Crowther has served as an advisor to Leo Pharma, Pfizer, Bayer, Boehringer Ingelheim, Alexion, CSL Behring, and Artisan Pharma; has prepared educational materials for Pfizer, Octapharm, and CSL Behring; has provided expert testimony for Bayer; and holds a Career Investigator award from the Heart and Stroke Foundation of Ontario and the Leo Pharma Chair in Thromboembolism Research at McMaster University. Dr Crowther's affiliated institution (McMaster University) has received funding for research projects from Boehringer Ingelheim, Octapharm, Pfizer, and Leo Pharma.
Funding/Support: CSL Behring LLC provided funding for the study.
Role of the Sponsor: CSL Behring LLC was not involved in the study design, collection, analysis, or interpretation of the data or in preparation and submission of the manuscript for publication.
Additional Contributions: Aubrey E. Jones assisted with the extraction of information from medical records.