Accepted for Publication: May 21, 2012.
Published Online: August 27, 2012. doi:10.1001/archinternmed.2012.3250
Author Contributions: Dr Brozek had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Brozek, Kraft, Krishnan, Lazarus, Li, Strunk, and Casale. Acquisition of data: Brozek, Kraft, Cloutier, Lazarus, Li, Santesso, Strunk, and Casale. Analysis and interpretation of data: Brozek, Kraft, Krishnan, Lazarus, Li, Strunk, and Casale. Drafting of the manuscript: Brozek, Kraft, Krishnan, Cloutier, Li, Strunk, and Casale. Critical revision of the manuscript for important intellectual content: Kraft, Cloutier, Lazarus, Li, Santesso, Strunk, and Casale. Statistical analysis: Brozek, Lazarus, and Li. Administrative, technical, and material support: Krishnan and Casale. Study supervision: Kraft and Casale.
Financial Disclosure: Relevant financial activities outside the submitted work include grants from GlaxoSmithKline, Merck, Asthmatix, Eumedics, Novartis, and Genentech (Duke University); personal and family stock ownership in Abbott, Novartis, and Johnson and Johnson (Dr Li); grants from AstraZeneca, Merck, Novartis, Genentech, and sanofi-aventis (Creighton University): and consultation for Boehringer Ingelheim on unrelated topics (Dr Casale).
Funding/Support: Dr Brozek holds a McMaster University Department of Medicine Internal Career Research Award. The American Academy of Allergy Asthma and Immunology and the American Thoracic Society provided staff support for conference calls and meetings.
Additional Contributions: We acknowledge the support and contributions of the American Academy of Allergy Asthma and Immunology and the American Thoracic Society.