For more than 15 years, all major clinical practice guidelines have recommended a target blood pressure (BP) of less than 130/80 mm Hg for patients with diabetes mellitus (DM).1 This BP value is based almost exclusively on the results of retrospective analyses of primary outcomes trials.
The first prospective trial to randomize patients with type 2 DM (T2DM) to target BPs and examine their cardiovascular (CV) outcomes was the UKPDS 38 by the United Kingdom Prospective Diabetes Study Group.2 In that trial, the group randomized to tighter BP control had a mean BP of 144/82 mm Hg and demonstrated significant reductions in DM-related deaths and complications compared with the group randomized to usual control, whose mean systolic BP was 10 mm Hg higher.
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