Accepted for Publication: April 9, 2012.
Published Online: June 18, 2012. doi:10.1001/archinternmed.2012.2782
Author Contributions: Drs Udell and Bhatt had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Udell, Steg, Scirica, Ohman, and Bhatt. Acquisition of data: Udell, Steg, and Eagle. Analysis and interpretation of data: Udell, Steg, Scirica, Smith, Eagle, Cho, and Bhatt. Drafting of the manuscript: Udell. Critical revision of the manuscript for important intellectual content: Udell, Steg, Scirica, Smith, Ohman, Eagle, Eagle, Cho, and Bhatt. Statistical analysis: Udell and Cho. Obtained funding: Udell and Steg. Administrative, technical, and material support: Ohman, Eagle, and Bhatt. Study supervision: Steg, Scirica, Eagle, and Bhatt.
Financial Disclosure: Dr Steg has been a consultant or on advisory boards for Ablynx, Astellas, AstraZeneca, Bayer, Boehringer-Ingelheim, BMS, Daiichi-Sankyo-Lilly, Eisai, GlaxoSmithKline, Medtronic, MSD, Pfizer, Roche, sanofi-aventis, Servier, and The Medicines Co, and is a stockholder and cofounder of Aterovax. Dr Scirica has received grants for clinical research via the TIMI Study Group and Brigham and Women's Hospital from AstraZeneca Pharmaceuticals LP, Daiichi-Sankyo Inc, Merck & Co Inc, Johnson & Johnson Pharmaceutical Research and Development LLC, Bayer HealthCare Pharmaceuticals, Bristol-Myers-Squibb Co, and Gilead Science, and has served as a consultant for Gilead Sciences Inc, Arena Pharmaceuticals, and Lexicon. Dr Ohman's university salary is partially supported by Daiichi-Sankyo and Maquet, and he has been a consultant for AstraZeneca, Boehringer-Ingelheim, Bristol Myers Squibb, Gilead Sciences, Liposcience, Merck, Pozen Inc, Roche, sanofi-aventis, The Medicines Co, and WebMD. Dr Goto has received research grants from sanofi-aventis, Eisai, and Boehringer-Ingelheim, and has been a consultant or on advisory boards for Eisai, sanofi-aventis, and Otsuka. Dr Bhatt has been on the advisory board for Medscape Cardiology; on the board of directors for Boston VA Research Institute and the Society of Chest Pain Centers; the chair for the American Heart Association Get With The Guidelines Science Subcommittee; received honoraria from the American College of Cardiology (editor, Clinical Trials, Cardiosource), Duke Clinical Research Institute (clinical trial steering committees) and Slack Publications (chief medical editor, Cardiology Today Intervention), WebMD (CME steering committees); has received research grants from Amarin, AstraZeneca, Bristol-Myers Squibb, Eisai, Ethicon, Medtronic, sanofi aventis, and The Medicines Company; and has done unfunded research for PLx Pharma and Takeda.
Funding/Support: The REACH Registry is sponsored by sanofi-aventis, Bristol-Myers Squibb, and the Waksman Foundation (Tokyo, Japan). The REACH Registry is endorsed by the World Heart Federation. Dr Udell is a recipient of a Postdoctoral Research Fellowship from the Canadian Institutes for Health Research and Canadian Foundation for Women's Health.
Role of the Sponsors: The design and conduct of the REACH study were done by the academic executive committee in collaboration with the sponsors; the collection and management of the data were done by the sponsors under the direction of the academic executive committee.
Disclaimer: The funding sources had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Previous Presentation: This study was presented as an abstract at the 2011 AHA Scientific Sessions; November 16, 2011; Orlando, Florida.
Online Only Material: An audio author interview is available here.