Accepted for Publication: April 15, 2012.
Published Online: June 4, 2012. doi:10.1001/archinternmed.2012.2266
Author Contributions: Dr Pilote had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Ionescu-Ittu, Jackevicius, Essebag, and Pilote. Acquisition of data: Richard and Pilote. Analysis and interpretation of data: Ionescu-Ittu, Abrahamowicz, Jackevicius, Essebag, Eisenberg, Wynant, and Pilote. Drafting of the manuscript: Ionescu-Ittu and Abrahamowicz. Critical revision of the manuscript for important intellectual content: Abrahamowicz, Jackevicius, Essebag, Eisenberg, Wynant, Richard, and Pilote. Statistical analysis: Ionescu-Ittu, Abrahamowicz, Wynant, and Richard. Obtained funding: Abrahamowicz, Jackevicius, and Pilote. Administrative, technical, and material support: Essebag and Pilote. Study supervision: Essebag, Eisenberg, and Pilote.
Financial Disclosure: None reported.
Funding/Support: This research was supported by the Canadian Institutes for Health Research (CIHR), grants MOP-8127, to Dr Abrahamowicz, a principal investigator, and MOP-84304, to Drs Jackevicius and Pilote, also principal investigators. Dr Essebag is the recipient of a Clinician Scientist Award from the CIHR. Dr Ionescu-Ittu is supported by a postdoctoral fellowship from Fonds de Recherche en Santé du Québec, and Drs Eisenberg and Pilote are national researchers for the Fonds de la Recherche en Santé du Québec. Drs Abrahamowicz and Pilote hold James McGill Research Chairs at McGill University.
Role of the Sponsors: The funding agencies had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Previous Presentations: This study (preliminary results) was a poster presentation at the 2010 Canadian Cardiovascular Congress; October 23-27, 2010; Montréal, Quebec; and the abstract was given as an oral presentation at the 2011 North American Congress of Epidemiology; June 21-24, 2011; Montréal, Québec (abstract published in Am J Epidemiol. 2011;173[suppl 11]:636-S).