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A STUDY OF THE RENAL CONCENTRATION POWER FOR URIC ACID IN EARLY CHRONIC INTERSTITIAL NEPHRITIS:  PRELIMINARY PAPER

ROY UPHAM, M.D.; HENRY ALLEN HIGLEY, M.D.
Arch Intern Med (Chic). 1919;24(5):557-562. doi:10.1001/archinte.1919.00090280088010.
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In 1916 Myers and Fine1 published a series of cases showing an increase of blood uric acid in early chronic interstitial nephritis. In later cases of this disease they showed an increase of blood urea and creatinin. Subsequently, in 1919 the same authors2 drew attention to the fact that uric acid, urea and creatinin pass through the renal membrane with different degrees of ease. The kidney concentrates uric acid approximately twenty times, while it concentrates urea and creatinin approximately eighty and one hundred times, respectively.

With the above work as a point of departure, we instituted a series of studies regarding the renal concentration power for uric acid in early chronic interstitial nephritis with the thought that the findings might be utilized for accurate results in the early diagnosis of that disease.

The scope of the work is naturally divided as follows:

  1. A study of the renal concentration power for

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