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Pulmonary Renal Syndrome and Thrombotic Thrombocytopenic Purpura in a Patient With Giant Cavernous Hemangioma of the Leg

W. Y. Au, MRCP; S. C. Tang, MRCP; K. W. Chan, FRCPath; K. K. Wong, FHKCR; C. G. C. Ooi, FRCR
Arch Intern Med. 2002;162(2):222-223. doi:.
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The microangiopathic hemolytic disorders cover a wide spectrum of clinical disorders and have a variety of underlying and triggering causes. Early diagnosis and treatment are essential to minimize organ damage and improve prognosis.

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A, Giant hemangioma with congenital hemihypertrophy of the leg. B, Extent of the hemangioma shown on red blood cell scan. C, An extensive fibrocellular crescent (arrows) with displaced and collapsed glomerular tufts (arrowheads) (periodic acid–Schiff stain, original magnification ×400). D, The glomerular basement membrane showed multiple areas of irregular thickening, duplication, and mesangial cell interposition (arrowheads) (electron microscope, original magnification ×10 000).

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