Accepted for Publication: January 27, 2012.
Published Online: April 23, 2012. doi:10.1001/archinternmed.2012.402
Author Contributions: Drs Collet and Rodondi had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Gussekloo, Newman, Westendorp, Franklyn, and Rodondi. Acquisition of data: Gussekloo, den Elzen, Iervasi, Åsvold, Sgarbi, Völzke, Gencer, Maciel, Molinaro, Luben, Newman, Khaw, Westendorp, Franklyn, Walsh, and Rodondi. Analysis and interpretation of data: Collet, Gussekloo, Bauer, den Elzen, Cappola, Balmer, Iervasi, Åsvold, Sgarbi, Völzke, Gencer, Maciel, Bremner, Maisonneuve, Cornuz, Westendorp, Franklyn, Vittinghoff, and Rodondi. Drafting of the manuscript: Collet, Balmer, Maciel, Westendorp, and Franklyn. Critical revision of the manuscript for important intellectual content: Collet, Gussekloo, Bauer, Cappola, Balmer, Iervasi, Åsvold, Sgarbi, Völzke, Gencer, Molinaro, Bremner, Luben, Maisonneuve, Cornuz, Newman, Khaw, Westendorp, Franklyn, Vittinghoff, Walsh, and Rodondi. Statistical analysis: Collet, Gussekloo, Balmer, Gencer, Franklyn, Vittinghoff, and Rodondi. Obtained funding: Sgarbi, Völzke, Maciel, Newman, Khaw, Westendorp, Walsh, and Rodondi. Administrative, technical, and material support: Collet, den Elzen, Gencer, Maciel, Luben, Newman, Khaw, Franklyn, and Rodondi. Study supervision: Gussekloo, Iervasi, Molinaro, Westendorp, and Rodondi. Dr Vittinghoff reviewed the statistical analyses of the manuscript.
Financial Disclosure: None reported.
Funding/Support: This study was supported by a grant SNSF 320030-138267 from the Swiss National Science Foundation (principal investigator, Dr Rodondi). The Cardiovascular Health Study and the research reported in this article were supported by contracts N01-HC-80007, N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, and grant U01 HL080295 from the National Heart, Lung, and Blood Institute, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through grants R01 AG-15928, R01 AG-20098, AG-027058, and AG-032317 from the National Institute on Aging; grant R01 HL-075366 from the National Heart, Lung, and Blood Institute; and the University of Pittsburgh Claude. D. Pepper Older Americans Independence Center grant P30-AG-024827. The thyroid measurements in the Cardiovascular Health Study were supported by an American Heart Association Grant-in-Aid (to Linda Fried, MD). A full list of principal Cardiovascular Health Study investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm. The Health, Aging, and Body Composition Study was supported by National Institute on Aging (NIA) contracts N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; NIA grant R01-AG028050; and National Institute of Nursing Research grant R01-NR012459. The NIA funded the Health, Aging, and Body Composition Study, reviewed the manuscript, and approved its publication. The EPIC-Norfolk study was supported by research grants from the Medical Research Council UK and Cancer Research UK. The Nord-Trøndelag Health Study (HUNT Study) is a collaborative effort of HUNT Research Center, Faculty of Medicine, Norwegian University of Science and Technology; Nord-Trøndelag County Council; Central Norway Health Authority; and the Norwegian Institute of Public Health. The thyroid function testing in the HUNT Study was financially supported by Wallac Oy (Turku, Finland). The Leiden 85-Plus Study was partly funded by the Dutch Ministry of Health, Welfare, and Sports. The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research, the Ministry of Cultural Affairs, as well as the Social Ministry of the Federal State of Mecklenburg–West Pomerania. Analyses were further supported by a grant of the German Research Foundation (DFG Vo 955/5-2). The Brazilian Thyroid Study was supported by an unrestricted grant from the Sao Paulo State Research Foundation (Fundacão de Amparo a’ Pesquisa do Estado de Sao Paulo, FAPESP, grant 6/59737-9 to Dr Maciel). Dr Newman is supported by grant AG-023629 from the NIA. Dr Westendorp is supported by the Netherlands Organization for Scientific Research (NGI/NWO 911-03-016).
Role of the Sponsor: None of the sponsors had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript; except for the NIA, which funded the Health, Aging, and Body Composition Study, reviewed the manuscript, and approved its publication.
Participating Studies of the Thyroid Studies Collaboration:United States: Cardiovascular Health Study; Health, Aging, and Body Composition Study; United Kingdom: Birmingham Study and EPIC-Norfolk Study; Norway: Nord-Trøndelag Health Study (HUNT Study); the Netherlands: Leiden 85-Plus Study; Italy: Pisa Cohort; Germany: Study of Health in Pomerania; Australia: Busselton Health Study; and Brazil: Brazilian Thyroid Study.
Online-Only Material: Visit http://www.archinternmed.com to listen to an author podcast about this article.