Author Contributions: All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Voss and Liu-Ambrose. Acquisition of data: Nagamatsu, Hsu, and Liu-Ambrose. Analysis and interpretation of data: Nagamatsu, Handy, Voss, and Liu-Ambrose. Drafting of the manuscript: Nagamatsu, Handy, and Liu-Ambrose. Critical revision of the manuscript for important intellectual content: Nagamatsu, Handy, Hsu, Voss, and Liu-Ambrose. Statistical analysis: Nagamatsu, Voss, and Liu-Ambrose. Obtained funding: Liu-Ambrose. Administrative, technical, and material support: Nagamatsu, Hsu, Voss, and Liu-Ambrose. Study supervision: Handy and Liu-Ambrose.
Financial Disclosure: None reported.
Funding/Support: The Pacific Alzheimer's Research Foundation provided funding for this study (Dr Liu-Ambrose).
Previous Presentation: Data from this manuscript were presented as a podium presentation at the International Society for Neuroimaging in Psychiatry; September 9, 2011; Heidelberg, Germany.
Additional Information: Ms Nagamatsu is a Michael Smith Foundation for Health Research Senior Graduate trainee and a Natural Sciences and Engineering Research Council of Canada Doctoral trainee. Dr Liu-Ambrose is a Michael Smith Foundation for Health Research Scholar, a Canadian Institutes of Health Research New Investigator, and a Heart and Stroke Foundation of Canada's Henry J. M. Barnett's Scholarship recipient.
Additional Contributions: Alison Chan, BSc, Jennifer C. Davis, PhD, B. Lynn Beattie, MD, and Peter Graf, PhD, made significant contributions to this study. We thank the instructors for their commitment to the participants' health and safety.