Accepted for Publication: December 9, 2011.
Published Online: February 27, 2012. doi:10.1001/archinternmed.2011.1977
Author Contributions: Dr Solomon had access to all the data and takes full responsibility for the accuracy and completeness of the data and the data analysis. Study concept and design: Solomon, Iversen, Avorn, Patrick, Shrank, Losina, and Katz. Acquisition of data: Solomon, Avorn, Gleeson, and Rekedal. Analysis and interpretation of data: Solomon, Iversen, Avorn, Gleeson, Brookhart, Patrick, Shrank, Lii, Losina, and Katz. Drafting of the manuscript: Solomon, Iversen, Brookhart, and Lii. Critical revision of the manuscript for important intellectual content: Solomon, Iversen, Avorn, Gleeson, Patrick, Rekedal, Shrank, Losina, and Katz. Statistical analysis: Solomon, Brookhart, Patrick, Shrank, Lii, and Losina. Obtained funding: Drs Solomon and Katz. Administrative, technical, and material support: Solomon, Iversen, Gleeson, Rekedal, and Katz. Study supervision: Solomon, Iversen, Avorn, Gleeson, Shrank, and Katz.
Financial Disclosure: In the past 3 years, Dr Solomon has received research grants regarding rheumatoid arthritis from Amgen, Abbott Immunology, and Eli Lilly and Company; has received an educational grant for a clinical research course from Bristol-Myers Squibb; and has served as an unpaid member of a data safety monitoring board for a Pfizer-sponsored trial on analgesics and an unpaid member of an executive committee for a Pfizer-sponsored trial on nonsteroidal anti-inflammatory drugs. Dr Brookhart has received research support from Amgen and Rockwell Medical, has been an unpaid member of advisory boards for Pfizer and Amgen, and has received consulting fees from World Health Information Consultants, McKesson Health Solutions, Kaiser Permanente, and Crimson Health. Dr Shrank has received research support from CVS Caremark.
Funding/Support: This study was supported by grant P60 AR047782 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH). Other salary support was obtained from grants K24 AR055989 (Dr Solomon), K23 HL090505 (Dr Shrank), K24 AR057827 (Dr Losina), K24 AR02123 (Dr Katz), and K25 AG027400 (Dr Brookhart) from the NIH.
Online-Only Material: The eMaterials are available from the authors on request.
Additional Contributions: Douglas C. Bauer, MD, MPH (Departments of Medicine and Epidemiology and Biostatistics, University of California–San Francisco), served as the NIH-appointed safety officer for this study and received payment from the NIH for these services. We thank Pennsylvania’s Pharmaceutical Assistance Contract for the Elderly for their assistance with this project.