We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Dronedarone Use and Fatal Lung Toxic Effects?  Comment on “Fatal Lung Toxicity Related to Dronedarone Use”

Nora Goldschlager, MD
Arch Intern Med. 2012;172(6):517. doi:10.1001/archinte.172.6.517.
Text Size: A A A
Published online


Siu et al have observed a rare potential adverse effect of dronedarone in patients who have had previous exposure to amiodarone. Dronedarone is an antiarrhythmic agent that can be useful in some patients with nonpermanent atrial fibrillation who have not had recent heart failure. Many clinicians, including cardiologists, are currently using this drug in specific patient populations, including young individuals, at least initially, in preference to long-term oral therapy with amiodarone, a more highly toxic agent. Nonetheless, it is clinical observations like these, and not randomized controlled studies, which can (and often do) serve the purpose of alerting us to new and important consequences of our therapies. The implied warning provided by this report in these 2 patients who have had prior exposure to amiodarone should be taken seriously, and newly described adverse effects should be actively sought and reported by physicians using newly developed approved drugs of all types.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.