Accepted for Publication: November 7, 2011.
Published Online: January 23, 2012. doi:10.1001/archinternmed.2011.1316
Author Contributions: Dr Mancuso had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Mancuso, Hollenberg, Isen, Jobe, Allegrante, and Charlson. Acquisition of data: Mancuso, Choi, Westermann, Wenderoth, Hollenberg, and Charlson. Analysis and interpretation of data: Mancuso, Westermann, Hollenberg, Wells, Isen, and Charlson. Drafting of the manuscript: Mancuso, Wenderoth, and Wells. Critical revision of the manuscript for important intellectual content: Mancuso, Choi, Westermann, Hollenberg, Wells, Isen, Jobe, Allegrante, and Charlson. Statistical analysis: Mancuso, Hollenberg, Wells, and Isen. Obtained funding: Mancuso, Allegrante, and Charlson. Administrative, technical, or material support: Mancuso, Westermann, Wenderoth, Hollenberg, Allegrante, and Charlson. Study supervision: Mancuso, Hollenberg, and Jobe.
Financial Disclosure: Dr Briggs received salary support for his contributions during the initial phase of the trial.
Funding/Support: This study was supported by contract N01 HC 25196 from the National Heart, Lung, and Blood Institute.
Role of the Sponsors: The funding agency participated in the design of the study, in the analysis and interpretation of the data, and in the preparation of the manuscript. The funding agency had no role in the conduct of the study or the collection or management of the data. The funding agency reviewed and approved the final manuscript.
Previous Presentation: This study was presented at the 2009 Annual Meeting (International Conference) of the American Thoracic Society; May 19, 2009; San Diego, California.
Additional Contributions: B. Robert Meyer, MD, and the physicians and patients at the Cornell Internal Medicine Associates at the Weill Cornell Medical College participated in this study. Mary Murray-Weir, PT, MBA, Hospital for Special Surgery, assisted in categorizing physical activities. William M. Briggs, PhD, New York Methodist Hospital, Brooklyn, New York, and Bohumir Prikryl, MS, Weill Cornell Medical College, assisted in managing databases.