The Relationship Between Clinical Benefit and Receipt of Curative Therapy for Prostate Cancer FREE

Life expectancy (LE) and tumor characteristics are clinical factors that affect the likelihood of benefit from curative therapy (CTx) for prostate cancer. Treatment of patients with a shorter LE may contribute to additional costs or complications, without a commensurate improvement in quality of life or survival.^1- 3 The National Comprehensive Cancer Network practice guidelines in oncology⁴ recommend active surveillance as an alternative to CTx (radical prostatectomy or radiation therapy) for patients with low-risk tumor characteristics who have an LE of less than 10 years. For patients with intermediate-risk cancers and an LE of 10 years or more, CTx is recommended.⁴ Although therapeutic options for patients with prostate cancer have expanded considerably in recent years, little is known about whether the treatment of men with early-stage prostate cancer has evolved.^5- 7 It is unclear whether patterns of care correspond to the likelihood of clinical benefit from treatment, as determined by LE and tumor characteristics. We therefore assessed trends in the use of CTx across strata of potential clinical benefit.

Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare–linked database, we identified men aged 67 to 84 years with localized prostate cancer that was diagnosed between 1998 and 2007, including only patients from registries that existed before the 2000 SEER expansion. We defined low-risk tumors as those with SEER grade 1 or 2 and stage T1 or T2a and moderate-risk tumors as those with SEER grade 3 or 4 or stage T2b-T2c.

A standard life table approach was used to estimate LE as a function of noncancer comorbidity.⁸ Specifically, we used a sample of patients without a cancer diagnosis recorded in SEER from the Medicare 5% random sample to determine annual mortality rates for each age and comorbidity stratum and then used these rates to estimate LE. Patients with an LE of less than 5 years, 5 to 10 years, or 10 years or more were classified as having a short, intermediate, or long LE. The 10-year survival rates in these groups were 19.3%, 51.6%, and 76.1%, respectively.

We defined CTx as receipt of radiation therapy or prostatectomy within 9 months of cancer diagnosis, as defined by International Classification of Diseases, Ninth Revision, procedure codes and Healthcare Common Procedure Coding System codes (eAppendix). Multivariable logistic regression was used to model the receipt of CTx after controlling for age, race, marital status, comorbidity, and SEER registry. χ² Tests were used to ascertain bivariate associations between the independent variables and the receipt of CTx. Interactions between LE and diagnosis year were assessed in low- and moderate-risk tumor groups.

The study sample was composed of 39 270 patients (median age, 74 years); 43.2% had moderate-risk tumors. Nearly 83% of patients were white and 9% were black; 55.0% had no comorbid conditions, 34.3% had 1 to 2 conditions, and 10.4% had 3 or more conditions. Of the patients in the full sample, 64.3% received CTx. There was a strong association between LE and receipt of CTx. Approximately 39.1% of 3557 patients with a short LE, 62.7% of 23 721 patients with an intermediate LE, and 75.1% of 11 992 patients with a long LE received CTx (P < .001).

Prostate cancer treatment rates increased over time. Overall, CTx increased from 61.2% to 67.6% from 1998 through 2007 (P < .001). Within each tumor-risk category, the increase in CTx use differed across LE groups. Among men with moderate-risk prostate cancer, there was a substantial increase in CTx rates in the short LE group (from 38.0% in 1998-1999 to 52.1% in 2006-2007 [Figure]). Conversely, the use of CTx decreased from 80.7% to 80.0% among men with a long LE (LE × Time Interaction, P = .02). Among men with low-risk tumors, the use of CTx trended downward for men in the long LE category but increased for men in the short and intermediate LE categories (LE × Time Interaction, P < .001).

Men with localized prostate cancer may not receive CTx in accordance with clinical benefit. During our study period, there was increasingly aggressive treatment of patients with a low likelihood of clinical benefit, without a commensurate increase in the treatment of patients with a high likelihood of clinical benefit. While not treating potentially fatal cancer can reflect poor-quality care, aggressive management of disease that is unlikely to progress puts patients at risk for morbidity and increases cost without medical benefits.^1- 3 Given widespread concerns about the rate of increase in Medicare expenditures, it is notable that the most substantial increase in treatment in our sample was noted among the patients who were least likely to benefit. Possible explanations include financial incentives, emergence of new therapies with perceived lower adverse effect profiles, and changes in patient preferences. The use of cancer therapies should be informed by clinical evidence and guided by patient preferences. Future work should explore how better to incorporate both cancer characteristics and patient LE into decision making.