Accepted for Publication: October 17, 2011.
Author Contributions: Drs Amin and Kosiborod and Ms Gosch had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Amin and Kosiborod. Acquisition of data: Kosiborod. Analysis and interpretation of data: Amin, Salisbury, McCullough, Gosch, Spertus, Venkitachalam, Stolker, Parikh, Masoudi, Jones, and Kosiborod. Drafting of the manuscript: Amin, McCullough, and Kosiborod. Critical revision of the manuscript for important intellectual content: Amin, Salisbury, McCullough, Gosch, Spertus, Venkitachalam, Stolker, Parikh, Masoudi, Jones, and Kosiborod. Statistical analysis: Amin, Gosch, Jones, and Kosiborod. Obtained funding: Kosiborod. Administrative, technical, and material support: Spertus and Kosiborod. Study supervision: Spertus and Kosiborod.
Financial Disclosure: Dr Spertushas received research support from ACCF, Johnson & Johnson, Amgen, Lilly, Evaheart, and Sanofi Aventis; has received other research support from Roche and Atherotech; and has been a consultant or member of an advisory board for St Jude Medical, United Healthcare, and Novartis. Dr Masoudi is on the advisory board of Amgen and has participated in blinded end-point adjudication for Axio Research. Dr Kosiborod has received research grants from Medtronic Diabetes and has been a consultant or a member of the advisory boards for Medtronic Diabetes, Sanofi-Aventis, Boehringer-Ingelheim, Kowa Pharmaceuticals, Gilead, and Genentech.
Funding/Support: Drs Amin, Salisbury, Spertus, and Kosiborod are funded, in part, by an award from the American Heart Association Pharmaceutical Round Table (AHA-PRT) and David and Stevie Spina. Dr Spertus has received a research grant from the National Heart, Lung, and Blood Institute and the AHA-PRT Outcomes Centers. Dr Masoudi has received funding from the National Heart, Lung, and Blood Institute and the AHA-PRT Outcomes Centers. Dr Kosiborod has received a research grant from the AHA.