How does the patient-centered medical home (PCMH) affect health care provider and staff morale, satisfaction, and burnout? This study surveyed 391 health care providers and 382 clinical staff members in 65 safety net clinics across 5 states beginning to adopt the PCMH model. Respondents were asked about their perceptions of current PCMH characteristics in their own clinic as well as their morale, satisfaction, and burnout. Characteristics of PCMHs were combined into 5 separate domains (access and communication with patients, communication with other providers, tracking data, care management, and quality improvement) as well as a total PCMH score. Health care providers and staff who perceived more PCMH characteristics in their clinics were more likely to have higher morale but less provider freedom from burnout. Among the PCMH domains, quality improvement was particularly correlated with higher morale and satisfaction and lower burnout.