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Clinical Observation |

Heparin Treatment for Severe Hypertriglyceridemia in Diabetic Ketoacidosis

Randolph P. Cole, MD
Arch Intern Med. 2009;169(15):1439-1441. doi:10.1001/archinternmed.2009.221.
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In a patient with diabetic ketoacidosis complicated by severe elevation of plasma triglyceride concentrations, treatment with low-level intravenous unfractionated heparin led to prompt reduction in plasma triglyceride concentration and may have prevented the development of hypertriglyceridemia-associated acute pancreatitis. This article reviews the rationale for this treatment and surveys prior publications using heparin in this and similar settings.

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Plasma triglyceride concentration during low-dose heparin therapy. To convert triglycerides to millimoles per liter, multiply by 0.0113.

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Concerns about heparin therapy for hypertriglyceridemia. Arch Intern Med 2010;170(1):108-9; author reply 109.
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