Author Contributions: All the authors contributed to the final version of the manuscript. Dr Gallus had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: La Vecchia, Zuccaro, and Paleari, Cesario, Russo, and Apolone. Acquisition of data: Colombo and Zuccaro. Analysis and interpretation of data: Gallus, Tramacere, Cesario, Russo, Apolone, and Apolone. Drafting of the manuscript: Gallus and Tramacere. Critical revision of the manuscript for important intellectual content: La Vecchia, Colombo, Zuccaro, Paleari, Cesario, Russo, and Apolone. Statistical analysis: Tramacere. Obtained funding: La Vecchia and Zuccaro. Administrative, technical, and material support: Apolone. Study supervision: Gallus, La Vecchia, Colombo, Zuccaro, Paleari, Cesario, Russo, and Apolone.