0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Is Varenicline Effectiveness Declining in Randomized Trials?

Ranjit K. Dhelaria, MD, MRCP; Michael Rothberg, MD
Arch Intern Med. 2011;171(19):1770-1772. doi:10.1001/archinternmed.2011.493.
Text Size: A A A
Published online

Extract

In their recent study of varenicline tartrate, Hajek et al1 found that beginning therapy 4 weeks before the target quit date improved 12-week abstinence rates compared with the usual practice of beginningtherapy 1 week before quitting. It is interesting to note that the 47.2% abstinence rate in the intervention group is almost identical to the rates observed in previous randomized trials of varenicline (42%-47%) in which therapy was started only 1 week before quitting.25 More perplexing is the strikingly low quit rate of 20.8% in the placebo group, which received a regimen similar to that of active participants in the previous studies. At the same time, the rate of reported nausea—59% in the active group and 48% in the placebo group—was twice that previously reported.

Topics

varenicline

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

October 24, 2011
Peter Hajek, PhD; Hayden McRobbie, MB, ChB, PhD; Katie Myers, MSc; John Stapleton, MSc; Al-Rehan Dhanji, MBBS, MRCS
Arch Intern Med. 2011;171(19):1770-1772. doi:10.1001/archinternmed.2011.494.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();