In a previous study of acute experimental cocaine poisoning and its treatment1 we reported the following observations from experiments on the dog and the rabbit:
Death in acute poisoning from the hypodermic injection of cocaine hydrochloride is due to respiratory failure.
By the intravenous administration of appropriate hypnotics, e. g., barbital sodium (barbitalum soluble, U. S. P. X) with paraldehyde, the minimal lethal dosage of cocaine was raised from approximately 100 mg. per kilogram to 150 mg. per kilogram in the rabbit, and from approximately 26 mg. per kilogram to 65 mg. per kilogram in the dog. Convulsions ceased immediately during the injection of the hypnotics.
The convulsions caused by cocaine are largely of cortical origin; this disturbance contributes or is parallel to the more direct drug injury of the medullary centers, particularly the respiratory center. If the cortical manifestations of cocaine poisoning were controlled by hypnotics it was