Accepted for Publication: April 8, 2011.
Author Contributions: Dr Middleton had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Manini, Tylavsky, and Everhart. Acquisition of data: Simonsick and Harris. Analysis and interpretation of data: Middleton, Manini, Barnes, Brach, and Yaffe. Drafting of the manuscript: Middleton, Manini, and Tylavsky. Critical revision of the manuscript for important intellectual content: Middleton, Manini, Harris, Barnes, Brach, Everhart, and Yaffe. Statistical analysis: Middleton and Manini. Obtained funding: Harris, Tylavsky, and Everhart. Administrative, technical, and material support: Simomsick, Harris, and Yaffe. Study supervision: Yaffe.
Published Online: July 19, 2011. doi:10.1001/archinternmed.2011.277
Financial Disclosure: None reported.
Funding/Support: This work was supported by National Institute on Aging (NIA) contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106. This research was also supported in part by the Intramural Research Program of the National Institutes of Health, National Institute on Aging, and with additional support from the National Institute of Diabetes and Digestive and Kidney Diseases. Dr Middleton is supported by a Canadian Institute of Health Research fellowship; Dr Manini is supported by grant P30AG028740 from the National Institute on Aging Claude D. Pepper Center; Dr Barnes was supported in part by grant K01-AG-024069 from the National Institute on Aging and grant IIRG-06-27306 from the Alzheimer's Association; Dr Brach is supported in part by a National Institutes on Aging and American Federation of Aging Research Paul Beeson Career Development Award (K23 AG026766-01); and Dr Yaffe is supported in part by NIA grant AG 031155 and an Independent Investigator Award from the Alzheimer's Association.
Role of the Sponsors: None of the funding agencies had any role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.