Accepted for Publication: August 15, 2011.
Author Contributions: Dr Tonelli had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Bello and Tonelli. Acquisition of data: Hemmelgarn, Klarenbach, Manns, Bello, and Tonelli. Analysis and interpretation of data: Shurraw, Hemmelgarn, Lin, Majumdar, Bello, James, Turin, and Tonelli. Drafting of the manuscript: Shurraw, Hemmelgarn, Lin, Bello, and Tonelli. Critical revision of the manuscript for important intellectual content: Shurraw, Hemmelgarn, Majumdar, Klarenbach, Manns, Bello, James, and Tonelli. Statistical analysis: Shurraw, Lin, Majumdar, Bello, Turin, and Tonelli. Obtained funding: Manns. Administrative, technical, and material support: Hemmelgarn and Manns. Study supervision: Tonelli.
Financial Disclosure: None reported.
Funding/Support: This work was funded by an operating grant from the Heart and Stroke Foundation of Canada, and by an interdisciplinary team grant from the Alberta Heritage Foundation for Medical Research (AHFMR). Drs Hemmelgarn, Tonelli, Majumdar, and Klarenbach were supported by career salary awards from the AHFMR. Dr Tonelli was also supported by a Government of Canada Research Chair. Drs Hemmelgarn, Klarenbach, Manns, and Tonelli were all supported by a joint initiative between Alberta Health and Wellness and the Universities of Alberta and Calgary.
Role of the Sponsor: The funding organizations played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.