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Editor's Correspondence |

Adverse Drug Events Due to Potentially Inappropriate Medications—Reply

Denis O’Mahony, MD, FRCPI; Hilary Jane Hamilton, MB, MRCPI; Paul F. Gallagher, PhD, MRCPI; Cristin Ryan, PhD, MPSI; Stephen Byrne, PhD, MPSI
Arch Intern Med. 2011;171(21):1960-1961. doi:10.1001/archinternmed.2011.554.
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We note the comments of Drs Sakuma and Morimoto, suggesting caution when interpreting the data in our study published in the Archives on June 13.1 Their first point refers to “retrospectively collected” ADE data in our study. This was not the case. Data were collected prospectively at the point of admission, when World Health Organization–Uppsala Monitoring Committee (WHO-UMC) criteria for ADE detection were applied. Only those cases in which WHO-UMC criteria indicated a “probable” or “definite” ADE on admission to hospital were considered by the local expert panel for determination of whether the ADE was causal or contributory to the index hospitalization or an incidental finding. Furthermore, the local expert panel were not aware of whether these patients were taking Beers or STOPP criteria PIMs during their deliberations on the presence or absence of ADEs.

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Correspondence

November 28, 2011
Mio Sakuma, MD, PhD, MPH; Takeshi Morimoto, MD, PhD, MPH
Arch Intern Med. 2011;171(21):1960-1961. doi:10.1001/archinternmed.2011.553.
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