0
Research Letters |

Invited Commentary—Efforts to Optimize Patient Benefit From Inferior Vena Cava Filters FREE

Tracy Minichiello, MD
[+] Author Affiliations

Author Affiliation: Department of Medicine, University of California, San Francisco.


Arch Intern Med. 2011;171(21):1956-1959. doi:10.1001/archinternmed.2011.527.
Text Size: A A A
Published online

Theoretically, retrievable inferior vena cava (IVC) filters offer the advantage of prevention of pulmonary embolism (PE) without the associated risks of long-term permanent devices. Confidence in the efficacy and safety of retrievable IVC filters has led to a doubling in the placement of these devices over the past decade.1 However, Medicare database analysis showed that of the 65 041 devices placed in 2008, only an estimated 15% were retrieved.1 As these devices may be associated with significant complications, which increase over time, including a high risk of future deep vein thrombosis (DVT) and IVC thrombosis, all efforts should be made to avoid unnecessary long indwelling time. The US Food and Drug Administration (FDA) released a statement in August 2010 urging clinicians to remove these devices as soon as the risk of PE has subsided. This was based on finding nearly 1000 reported complications associated with these devices, a review prompted by an article published in the Archives that described an alarmingly high filter fracture rate with certain devices.2,3

Barriers to IVC filter retrieval include physician refusal, perhaps due to lack of appreciation for consequences of permanent devices, ongoing contraindication to anticoagulation, long indwelling time, and loss of patients to follow-up. To decrease the number of IVC filters that are left in place permanently, we should first help educate clinicians to identify appropriate candidates for placement. Recent studies suggest that only half of all IVC filter placements were appropriate per professional society guidelines.4 Next, a system should be in place to track the fate of the device. Leaving this up to the patient or primary care physician is not acceptable. Institution of an IVC filter clinic has been show to result in a 2-fold increase in retrieval rates.5 A weekly multidisciplinary review of filter placement request and indication, repositioning, and retrieval resulted in an 80% reduction in retained devices without an absolute indication.6 Mandatory postmarketing registries would provide a way to assess safety and efficacy of various devices and could provide valuable information on both complication retrieval rates.

In this issue of the Archives, Godoy-Garcia and colleagues7 advance this field further with their report of their experience with removal of IVC filters after a prolonged indwelling time. In their cohort, the most common indication for placement was prevention of venous thromboembolism (VTE) when pharmacologic prophylaxis was contraindicated (53%), followed by VTE despite anticoagulation (31%) and contraindications to anticoagulation secondary to bleeding complications in patients with known VTE (9%).

While the only available randomized control trial evaluating IVC filter efficacy shows a reduction in both short- and long-term recurrence of PE in patients with acute DVT, these patients all received anticoagulation and therefore were not representative of the patients who most commonly receive these devices.8,9 There is currently no high-level data to support the most common use of IVC filters, that is prevention of VTE in patients who are not on anticoagulation.

The controversy surrounding patient selection for IVC filter placement is reflected in the disparate recommendations found in guidelines from various sources (Table). The only currently agreed-on indication for IVC filter placement is prevention of PE in the setting of DVT and a contraindication to anticoagulation. Other indications remain controversial. While filters were once commonly placed in patients who developed recurrent or progressive DVT or PE despite anticoagulation, now most experts recommend an increase in intensity of anticoagulation or initiation of an alternative anticoagulant rather than placement of a device. Despite practitioners' concerns, free-floating thrombus has not been associated with increased risk of embolization and is not an indication for device placement. Inferior vena cava filters are often considered in patients with recent PE, poor cardiopulmonary reserve, and residual proximal DVT, but the lack of demonstrated mortality benefit challenges this practice.

Table Graphic Jump LocationTable. Recommendations for IVC Filter Placement

Because retrievable filters often become permanent, the risk-benefit analysis performed prior to placement should involve weighing the long-term consequences of recurrent DVT and IVC thrombosis with reduction in nonfatal PE. Inferior vena cava filters should be used primarily in patients who have acute VTE with an absolute contraindication to anticoagulation and should be removed as soon as full-dose anticoagulation can be safely tolerated. Health care providers should remember that while these devices may decrease the risk of PE, they do not prevent DVT nor are they a substitute for anticoagulant treatment of VTE. While recommended retrieval time varies by filter type, Godoy-Garcia and colleagues7 offer data to suggest that later removal was relatively safe for those devices studied. Through a combination of increasing appropriate use, increased retrieval, and more data on safety and efficacy, we can optimize patient benefit from use of these filters.

Correspondence: Dr Minichiello, Department of Medicine, University of California, San Francisco, 4150 Clement St, San Francisco, CA 94121 (minichie@medicine.ucsf.edu).

Financial Disclosure: None reported.

Duszak R Jr, Parker L, Levin DC, Rao VM. Placement and removal of inferior vena cava filters: national trends in the medicare population.  J Am Coll Radiol. 2011;8(7):483-489
PubMed   |  Link to Article
Nicholson W, Nicholson WJ, Tolerico P,  et al.  Prevalence of fracture and fragment embolization of Bard retrievable vena cava filters and clinical implications including cardiac perforation and tamponade.  Arch Intern Med. 2010;170(20):1827-1831
PubMed   |  Link to Article
US Food and Drug Administration.  Inferior vena cava (IVC) filters: initial communication: risk of adverse events with long term use. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm221707.htm. Accessed August 28, 2011
Spencer FA, Bates SM, Goldberg RJ,  et al.  A population-based study of inferior vena cava filters in patients with acute venous thromboembolism.  Arch Intern Med. 2010;170(16):1456-1462
PubMed   |  Link to Article
Minocha J, Idakoji I, Riaz A,  et al.  Improving inferior vena cava filter retrieval rates: impact of a dedicated inferior vena cava filter clinic.  J Vasc Interv Radiol. 2010;21(12):1847-1851
PubMed   |  Link to Article
Irwin E, Byrnes M, Schultz S,  et al.  A systematic method for follow-up improves removal rates for retrievable inferior vena cava filters in a trauma patient population.  J Trauma. 2010;69(4):866-869
PubMed   |  Link to Article
Godoy-Garcia F, Collins  T, Sacks D, Vasas S, Sarani B. Retrieval of inferior vena caval filters after prolonged indwelling time.  Arch Intern Med. 2011;171(21):1953-1955
Link to Article
Decousus H, Leizorovicz A, Parent F,  et al; Prévention du Risque d’Embolie Pulmonaire par Interruption Cave Study Group.  A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis.  N Engl J Med. 1998;338(7):409-415
PubMed   |  Link to Article
PREPIC Study Group.  Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prevention du Risque d’Embolie Pulmonaire par Interruption Cave) randomized study.  Circulation. 2005;112(3):416-422
PubMed   |  Link to Article
Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ.American College of Chest Physicians.  Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).  Chest. 2008;133(6):(suppl)  454S-545S
PubMed   |  Link to Article
Jaff MR, McMurtry MS, Archer SL,  et al; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology.  Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association.  Circulation. 2011;123(16):1788-1830
PubMed   |  Link to Article
Baglin TP, Brush J, Streiff M.British Committee for Standards in Haematology Writing Group.  Guidelines on use of vena cava filters.  Br J Haematol. 2006;134(6):590-595
PubMed   |  Link to Article
Geerts W. Clinical guide—inferior vena cava filters. http://www.tigc.org/clinical-guides/Inferior-Vena-Cava-Filters.aspx. Accessed September 21, 2011

Figures

Tables

Table Graphic Jump LocationTable. Recommendations for IVC Filter Placement

References

Duszak R Jr, Parker L, Levin DC, Rao VM. Placement and removal of inferior vena cava filters: national trends in the medicare population.  J Am Coll Radiol. 2011;8(7):483-489
PubMed   |  Link to Article
Nicholson W, Nicholson WJ, Tolerico P,  et al.  Prevalence of fracture and fragment embolization of Bard retrievable vena cava filters and clinical implications including cardiac perforation and tamponade.  Arch Intern Med. 2010;170(20):1827-1831
PubMed   |  Link to Article
US Food and Drug Administration.  Inferior vena cava (IVC) filters: initial communication: risk of adverse events with long term use. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm221707.htm. Accessed August 28, 2011
Spencer FA, Bates SM, Goldberg RJ,  et al.  A population-based study of inferior vena cava filters in patients with acute venous thromboembolism.  Arch Intern Med. 2010;170(16):1456-1462
PubMed   |  Link to Article
Minocha J, Idakoji I, Riaz A,  et al.  Improving inferior vena cava filter retrieval rates: impact of a dedicated inferior vena cava filter clinic.  J Vasc Interv Radiol. 2010;21(12):1847-1851
PubMed   |  Link to Article
Irwin E, Byrnes M, Schultz S,  et al.  A systematic method for follow-up improves removal rates for retrievable inferior vena cava filters in a trauma patient population.  J Trauma. 2010;69(4):866-869
PubMed   |  Link to Article
Godoy-Garcia F, Collins  T, Sacks D, Vasas S, Sarani B. Retrieval of inferior vena caval filters after prolonged indwelling time.  Arch Intern Med. 2011;171(21):1953-1955
Link to Article
Decousus H, Leizorovicz A, Parent F,  et al; Prévention du Risque d’Embolie Pulmonaire par Interruption Cave Study Group.  A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis.  N Engl J Med. 1998;338(7):409-415
PubMed   |  Link to Article
PREPIC Study Group.  Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prevention du Risque d’Embolie Pulmonaire par Interruption Cave) randomized study.  Circulation. 2005;112(3):416-422
PubMed   |  Link to Article
Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ.American College of Chest Physicians.  Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).  Chest. 2008;133(6):(suppl)  454S-545S
PubMed   |  Link to Article
Jaff MR, McMurtry MS, Archer SL,  et al; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology.  Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association.  Circulation. 2011;123(16):1788-1830
PubMed   |  Link to Article
Baglin TP, Brush J, Streiff M.British Committee for Standards in Haematology Writing Group.  Guidelines on use of vena cava filters.  Br J Haematol. 2006;134(6):590-595
PubMed   |  Link to Article
Geerts W. Clinical guide—inferior vena cava filters. http://www.tigc.org/clinical-guides/Inferior-Vena-Cava-Filters.aspx. Accessed September 21, 2011

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 4

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
JAMAevidence.com

Users' Guides to the Medical Literature
Table 9.2-3 Refuted Evidence From Observational Studiesa