Functional dyspepsia is a major burden to society. Upper gastrointestinal tract symptoms account for 5% of all primary care visits,1 and about 80% of patients with epigastric pain have a normal result from endoscopy.2- 3 The cost of investigating and treating this disorder is significant, and it is estimated that the US health care system spends over $1 billion per year on functional dyspepsia.1,4 Despite this drain on resources, there are few therapeutic options for patients with functional dyspepsia. A systematic review4 suggests that prokinetic therapy may have some benefit, but this is driven by small positive studies with the larger studies being negative, and any effect seen in the meta-analysis may be due to publication bias.5 Acid suppression with proton pump inhibitor therapy has modest efficacy in functional dyspepsia,6 and this may be due to the treatment of atypical gastroesophageal reflux disease.7 Given the paucity of effective therapies, it is important to establish whether eradicating Helicobacter pylori in those infected will have any benefit in functional dyspepsia.
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Figure. Forest plot of randomized controlled trials of Helicobacter pylori eradication vs placebo in H pylori –positive patients with functional dyspepsia: outcome relative risk (RR) of remaining dyspeptic. The current study8 is highlighted in red.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and
Association With Material Stature
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dhildhood mortality and growth failure data and their association with maternal
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