Accepted for Publication: April 8, 2011.
Published Online: July 25, 2011. doi:10.1001/archinternmed.2011.351
Author Contributions: Dr Paynter had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Paynter, Mazer, Ridker, and Cook. Acquisition of data: Paynter, Gaziano, Ridker, and Cook. Analysis and interpretation of data: Paynter, Mazer, Pradhan, Gaziano, and Cook. Drafting of the manuscript: Paynter. Critical revision of the manuscript for important intellectual content: Paynter, Mazer, Pradhan, Gaziano, Ridker, and Cook. Statistical analysis: Paynter and Cook. Obtained funding: Paynter, Mazer, and Ridker. Administrative, technical, and material support: Gaziano, Ridker, and Cook. Study supervision: Gaziano, Ridker, and Cook.
Financial Disclosure: Dr Paynter reports receiving investigator-initiated funding for this project from F. Hoffmann-La Roche, Ltd. Dr Mazer reports employment by and stock ownership in F. Hoffmann-La Roche, Ltd. Dr. Ridker reports receiving investigator-initiated funding from the Leducq Foundation, Roche Diagnostics, Amgen, Inc, AstraZeneca, Novartis, Merck, Abbott, and sanofi-aventis; consulting fees from AstraZeneca, Novartis, Merck Schering-Plough, sanofi-aventis, Isis, Siemens, and Vascular Biogenics; and is listed as a coinventor on patents held by Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in CVD, including the use of high-sensitivity C-reactive protein in the evaluation of patients' risk of CVD. These patents have been licensed to Siemens and AstraZeneca.
Funding/Support: This work was carried out with support from F. Hoffmann-La Roche Ltd; grants HL 043851, HL 080467, and CA 047988 for the Women's Health Study and grants CA 97193, CA 34944, CA 40360, HL 26490, and HL 34595 for the Physician's Health Study II from the National Heart Lung and Blood Institute and National Cancer Institute, Bethesda, Maryland; and the Donald W. Reynolds Foundation, Las Vegas, Nevada.
Role of the Sponsors: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation or review of the manuscript.