Accepted for Publication: April 26, 2011.
Published Online: August 8, 2011. doi:10.1001/archinternmed.2011.361
Author Contributions: Drs Salisbury and Kosiboro had full access to all the data in the study and take full responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Salisbury, Lai, and Kosiborod. Acquisition of data: Reid, Bach, and Kosiborod. Analysis and interpretation of data: Salisbury, Reid, Alexander, Masoudi, Lai, Chan, Bach, Wang, Spertus, and Kosiborod. Drafting of the manuscript: Salisbury, Reid, Wang, and Kosiborod. Critical revision of the manuscript for important intellectual content: Salisbury, Reid, Alexander, Masoudi, Lai, Chan, Bach, Spertus, and Kosiborod. Statistical analysis: Salisbury, Reid, Lai, and Kosiborod. Obtained funding: Spertus and Kosiborod. Administrative, technical, and material support: Wang, Spertus, and Kosiborod. Study supervision: Lai and Kosiborod.
Financial Disclosure: Dr Masoudi is on an advisory board for Amgen and has performed blinded end-point adjudication for Axio Research. Dr Bach has received research grants from AstraZeneca, Schering-Plough Corp, Merck & Co Inc, Bristol-Myers Squibb, The Medicines Co, and Eli Lilly and Co and has been a consultant (on a clinical events committee) for Roche Diagnostics, Eli Lilly and Co, Forest Laboratories, and Wyeth/Pfizer. Dr Wang has received research grants from Bristol-Myers Squibb/Sanofi, Daichi Sankyo, Canyon Pharmaceuticals, Eli Lilly and Co, Sanofi-Aventis, Schering Plough, Merck & Co Inc, and The Medicines Co and has been a consultant for Medco and AstraZeneca. Dr Spertus has received research grants from the National Heart, Lung, and Blood Institute, the American Heart Association Pharmaceutical Round Table (AHA-PRT), the American College of Cardiology Foundation Task Force, Johnson and Johnson, Amgen, Eli Lilly and Co, Evaheart Medical USA Inc, and Sanofi-Aventis; has received other research support from Roche Diagnostics and Atherotech Diagnostics Lab; and has been a consultant and/or member of an advisory board for St Jude Medical Inc, United Healthcare, and Novartis Pharmaceuticals Corp. Dr Kosiborod has been a consultant for Sanofi-Aventis and Boehringer-Ingelheim.
Funding/Support: Drs Salisbury, Spertus, and Kosiborod are funded in part by an award from the AHA-PRT and David and Stevie Spina.
Role of the Sponsors: The AHA had no role in the design, conduct, data collection, management, analysis, or interpretation of data, and had no role in preparation, review, or approval of the manuscript. The Cerner Corp facilitated collection and deidentification of the data but had no role in the funding of the study, design, conduct, management, analysis, or interpretation of the data, and had no role in preparation, review, or approval of the manuscript.