The essence of the timeless warning from Alexander Pope1 expressed in the present title is often lost through misquotation as “A little knowledge is a dangerous thing.” Pope's “essay” continues,1
Published 300 years later, 2 articles in this issue of the Archives re-examine our basis of evidence for cardiac resynchronization therapy (CRT).2,3 They provide vivid demonstration of how we may be intoxicated by the enthusiastic presentations of new trials2 and how we may be rendered sober again by deeper analysis of the collective experience3 as we seek to translate those trials for the patients who rely on our wisdom. It is remarkable that these lessons can be clearly exemplified even in relation to CRT, which offers carefully selected patients one of the most effective therapies for heart failure in terms of quality of life, freedom from hospitalization, and survival.
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