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Clinical Observation |

The Use of Dabigatran in Elderly Patients

Matthieu Legrand, MD; Joaquim Mateo, MD; Alice Aribaud; Sixtine Ginisty, MD; Pirayeh Eftekhari, MD; Patrice Tran Ba Huy, MD, PhD; Ludovic Drouet, MD, PhD; Didier Payen, MD, PhD
Arch Intern Med. 2011;171(14):1285-1286. doi:10.1001/archinternmed.2011.314.
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Recent approval by the US Food and Drug Administration (FDA) of dabigatran etexilate, an oral direct thrombin inhibitor, for the prevention of stroke in patients with atrial fibrillation will likely extend its administration in elderly patients. The risk of major overdosage of dabigatran etexilate in this population is, however, much increased owing to frequent renal function impairment, low body weight, drug interactions that cannot be detected with a routine coagulation test, and no antagonist available. We report herein 2 clinical cases, including 1 fatal case, illustrating our concern regarding the risk of bleeding events in elderly patients.

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