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Perspective | Less Is More

Dual Therapy Difficulties in Angiotensin Blockade for Proteinuria A Teachable Moment

Kenneth W. Hung, MD1; Judith Blaine, MD, PhD2; Sarah Faubel, MD2
[+] Author Affiliations
1Department of Medicine, University of Colorado, Aurora
2Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Aurora
JAMA Intern Med. 2014;174(9):1429-1430. doi:10.1001/jamainternmed.2014.3460.
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A man in his 60s with lymphoproliferative B-cell disorder, hypertension, and stage 3 chronic kidney disease (CKD) secondary to diabetic nephropathy presented for follow-up of his diabetic nephropathy.

Article InformationCorresponding Author: Kenneth W. Hung, MD, Department of Medicine, University of Colorado, 12631 E 17th Ave, B177, Academic Office 1, Aurora, CO 80045 (kenneth.hung@ucdenver.edu).

Published Online: August 4, 2014. doi:10.1001/jamainternmed.2014.3460.

Conflict of Interest Disclosures: None reported.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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Great points and a nice review of literature
Posted on August 5, 2014
Abdul Saadi , MD, FACP
Assistant Professor of Medicine Temple University School of Medicine
Conflict of Interest: None
Great sobering reminder of the potential hazards of using "soft", non mortality and safety endpoints focusing so much on proteinurea and not evaluating the long term safety of these regimens.
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