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Research Letter |

Effects of Ranolazine on Quality of Life Among Patients With Diabetes Mellitus and Stable Angina

Suzanne V. Arnold, MD, MHA1,2; Mikhail Kosiborod, MD1,2; Darren K. McGuire, MD, MHSC3; Yan Li, PhD1; Patrick Yue, MD4; Ori Ben-Yehuda, MD5; John A. Spertus, MD, MPH1,2
[+] Author Affiliations
1St Luke’s Mid America Heart Institute, Kansas City, Missouri
2University of Missouri–Kansas City
3University of Texas Southwestern Medical Center, Dallas
4Gilead Sciences, Foster City, California
5Cardiovascular Research Foundation, New York, New York
JAMA Intern Med. 2014;174(8):1403-1405. doi:10.1001/jamainternmed.2014.2120.
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In the Type 2 Diabetes Evaluation of Ranolazine in Subjects with Chronic Stable Angina (TERISA) trial, ranolazine reduced the frequency of angina episodes and use of sublingual nitroglycerin in patients with type 2 diabetes mellitus (T2DM) and stable angina, as assessed by a daily diary.1 Using data from the same trial, we evaluated the effect of ranolazine on a broader range of patients’ health status and quality of life.

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Cumulative Response Curve of Change in Seattle Angina Questionnaire (SAQ) Angina Frequency by Treatment Group

A, Entire study population; B, focuses on the most common changes from baseline to 8 weeks (86% of the study population). Cumulative response curves plotted change in SAQ angina frequency from baseline to 8 weeks on the x-axis and the percentage of patients who achieved at least that amount of change on the y-axis.

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