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Original Investigation |

Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

Richard D. Semba, MD, MPH1; Luigi Ferrucci, MD, PhD2; Benedetta Bartali, PhD3; Mireia Urpí-Sarda, PhD4,5; Raul Zamora-Ros, PhD4,5; Kai Sun, MS1; Antonio Cherubini, MD, PhD6; Stefania Bandinelli, MD7; Cristina Andres-Lacueva, PhD4,5
[+] Author Affiliations
1Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
2Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland
3New England Research Institute, Boston, Massachusetts
4Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Laboratory, Food Technology Reference Net and Nutrition and Food Safety Research Institute (XaRTA and INSA ), Pharmacy School, University of Barcelona, Barcelona, Spain
5Unit of Nutrition, Environment and Cancer, Cancer Epidemiology and Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
6Geriatrics and Geriatric Emergency Department, Istituto Nazionale di Riposo e Cura per Anziani V.E.II.–Istituto di Ricovero e Cura a Carattere Scientifico (INRCA-IRCCS), Ancona, Italy
7Azienda Sanitaria, Florence, Italy
JAMA Intern Med. 2014;174(7):1077-1084. doi:10.1001/jamainternmed.2014.1582.
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Importance  Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anticancer effects in humans and is related to longevity in some lower organisms.

Objective  To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans.

Design  Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study (“Aging in the Chianti Region”), 1998 to 2009 conducted in 2 villages in the Chianti area in a population-based sample of 783 community-dwelling men and women 65 years or older.

Exposures  Twenty-four–hour urinary resveratrol metabolites.

Main Outcomes and Measures  Primary outcome measure was all-cause mortality. Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease.

Results  Mean (95% CI) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. During 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (P = .67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer.

Conclusions and Relevance  In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality. Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.

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Submit a Comment
The truth is still far...
Posted on May 13, 2014
Richard Semba
Richard D. Semba, Luigi Ferrucci, Benedetta Bartali, Mireia Urpí-Sarda, Raul Zamora-Ros, Kai Sun, Antonio Cherubini, Stefania Bandinelli, Cristina Andrés-Lacueva. Livelli di resveratrolo e d
Conflict of Interest: Nessun potenziali conflitti o rilevanti interessi finanziari
The study is completely removed from the foundations of scientific credibility and clear support of those who are still trying to gain by speculating on the health of the population. The circulating levels of resveratrol after wine intake, unless it is consumed a tanker of red wine, is small and completely devoid of flashy effects. It's obvious that an effective supplementation requires plasma quantitative significantly higher than the consumption of table wine, in order to assess the effectiveness of an active revolutionary as resveratrol. Your study should at least point out that the people of Tuscany is delighted by the quality of the wine hired ...
Red wine and the French Paradox: another beautiful theory murdered by the ugly facts
Posted on May 21, 2014
David L. Keller, MD, FACP
Conflict of Interest: None Declared
The French paradox is the presence of low coronary heart disease (CHD) death rates in France, despite high levels of cholesterol and saturated fat in the French diet. This has been explained partially by a number of factors, including: French doctors under-reporting CHD on death certificates (this accounted for 20% of the paradox in one study); the fact that the French ingest ethanol in moderate doses continuously all day, every day, compared with other countries where most ethanol is consumed in binges on one or two days per week (ethanol binges produce less increase in HDL and inconsistent anti-platelet effects); the French eat large amounts of saturated fat from animal sources, compared with Americans who consume slightly less saturated fat overall, but much more of it is hydrogenated trans fat, which is thought to be more atherogenic; a time-lag effect whereby the CHD rates of today reflect fat consumption levels 30 or more years ago, when the French diet was less fatty compared with the U.S.; consumption of possibly protective fruits and vegetables is also higher in France than in the U.S.(1) French serum lipid levels do not explain the paradox: they have been shown to be very similar to levels in countries with lower fat consumption and higher CHD rates (2). The most widely touted theory has been that the French regularly consume red wine, which has antioxidants and anti-inflammatory components, such as polyphenols and resveratrol, which confer greater protection against atherosclerosis than the ethanol in wine can account for. This study provides observational evidence that red wine consumption (for which urinary resveratrol is an accurate marker) does not correlate with lower rates of CHD. A placebo-controlled double-blinded interventional study of pharmacological doses of resveratrol would be more conclusive, but might be hard to justify given these findings. The source of protection enjoyed by French hearts remains debatable.References1: Ferrières J, The French paradox: lessons for other countries. Heart. Jan 2004; 90(1): 107–111. PMCID: PMC17680132: Law M and Wald N. Why heart disease mortality is low in France: the time lag explanation BMJ. May 29, 1999; 318(7196): 1471–1480. PMCID: PMC1115846ReplyPermalinkShare Edit Delete
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