Accepted for Publication: January 29, 2014.
Published Online: April 21, 2014. doi:10.1001/jamainternmed.2014.981.
Study concept and design: Tosteson, Fryback, Hammond, Hanna, Pisano.
Acquisition of data: Fryback, Hammond, Hanna, Brown, Lindfors, Pisano.
Analysis and interpretation of data: Tosteson, Fryback, Hammond, Hanna, Grove, Wang, Pisano.
Drafting of the manuscript: Tosteson, Fryback, Hammond, Grove, Brown, Wang, Lindfors.
Critical revision of the manuscript for important intellectual content: Tosteson, Fryback, Hanna, Lindfors, Pisano.
Statistical analysis: Tosteson, Hammond, Hanna, Grove, Wang.
Obtained funding: Tosteson, Fryback, Pisano.
Administrative, technical, or material support: Tosteson, Fryback, Hammond, Brown, Lindfors, Pisano.
Study supervision: Tosteson, Pisano.
Conflict of Interest Disclosures: Dr Pisano reports grants received or pending from Alan Penn & Associates, Koning Corp, the US Department of Health and Human Services, Konica Minolta, Zumatek, Inc, and the National Science Foundation; and patents planned/pending or issued, assigned to University of North Carolina, Chapel Hill, Brookhaven Science Associates, and the University of Saskatchewan and to NextRay, Inc. Dr Pisano is also a cofounder and board member of NextRay, Inc.
Funding/Support: This study was supported by grants U01CA80098, U01CA80098-S1, U01CA79778, U0179778-S1, RC2/UC2CA148259, and U54CA163307 from the National Cancer Institute.
Role of the Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.