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Research Letter |

Left Anterior Fascicular Block and the Risk of Cardiovascular Outcomes

Jonas B. Nielsen, MD1,2; Sandra E. Strandberg, BSc1,2; Adrian Pietersen, MD3; Claus Graff, MSc, PhD4; Anders G. Holst, MD, PhD1,2 ; for the Copenhagen ECG Study
[+] Author Affiliations
1Department of Cardiology, Laboratory of Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
2Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark
3Copenhagen General Practitioners’ Laboratory, Copenhagen, Denmark
4Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
JAMA Intern Med. 2014;174(6):1001-1003. doi:10.1001/jamainternmed.2014.578.
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Left anterior fascicular block (LAFB) is considered a failure or delay of conduction in the left anterior fascicle.1 Despite the fact that little is known about the long-term prognosis associated with LAFB, it has generally been thought of as a benign electrocardiographic (ECG) finding.2 This view was recently challenged in an article by Mandyam et al,3 which reported an association between LAFB and an increased risk of atrial fibrillation (AF), heart failure (HF), and all-cause and cardiovascular death in individuals free of overt cardiovascular disease. However, the findings by Mandyam et al were limited by the fact that only 39 individuals with LAFB were eligible for inclusion. Using a large contemporary primary care population, we aimed to validate the findings of Mandyam et al by replicating their analyses in our population.

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